Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis

PURPOSE: Elevated lipogenesis regulated by sterol regulatory element-binding protein-1 (SREBP-1), a transcription factor playing a central role in lipid metabolism, is a novel characteristic of glioblastoma (GBM). The aim of this study was to identify effective approaches to suppress GBM growth by i...

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Publicat a:Clin Cancer Res
Autors principals: Geng, Feng, Cheng, Xiang, Wu, Xiaoning, Yoo, Ji Young, Cheng, Chunming, Guo, Jeffrey Yunhua, Mo, Xiaokui, Ru, Peng, Hurwitz, Brian, Kim, Sung-Hak, Otero, Jose, Puduvalli, Vinay, Lefai, Etienne, Ma, Jianjie, Nakano, Ichiro, Horbinski, Craig, Kaur, Balveen, Chakravarti, Arnab, Guo, Deliang
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093025/
https://ncbi.nlm.nih.gov/pubmed/27281560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2973
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