Glucose-mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

Tumorigenesis is associated with increased glucose consumption and lipogenesis, but how these pathways are interlinked is unclear. Here, we delineate a pathway in which EGFR signaling, by increasing glucose uptake, promotes N-glycosylation of sterol regulatory element-binding protein (SREBP) cleavag...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Cheng, Chunming, Ru, Peng, Geng, Feng, Liu, Junfeng, Yoo, Ji Young, Wu, Xiaoning, Cheng, Xiang, Euthine, Vanessa, Hu, Peng, Guo, Jeffrey Yunhua, Lefai, Etienne, Kaur, Balveen, Nohturfft, Axel, Ma, Jianjie, Chakravarti, Arnab, Guo, Deliang
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643405/
https://ncbi.nlm.nih.gov/pubmed/26555173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.09.021
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