Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas

Amplification of the epidermal growth factor receptor gene on double minutes is recurrently observed in cells of advanced gliomas, but the structure of these extrachromosomal circular DNA molecules and the mechanisms responsible for their formation are still poorly understood. By using quantitative...

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Main Authors: Vogt, Nicolas, Lefèvre, Sandrine-Hélène, Apiou, Françoise, Dutrillaux, Anne-Marie, Cör, Andrej, Leuraud, Pascal, Poupon, Marie-France, Dutrillaux, Bernard, Debatisse, Michelle, Malfoy, Bernard
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2004
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC509208/
https://ncbi.nlm.nih.gov/pubmed/15269346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402979101
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