Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas

Amplification of the epidermal growth factor receptor gene on double minutes is recurrently observed in cells of advanced gliomas, but the structure of these extrachromosomal circular DNA molecules and the mechanisms responsible for their formation are still poorly understood. By using quantitative...

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Detalhes bibliográficos
Main Authors: Vogt, Nicolas, Lefèvre, Sandrine-Hélène, Apiou, Françoise, Dutrillaux, Anne-Marie, Cör, Andrej, Leuraud, Pascal, Poupon, Marie-France, Dutrillaux, Bernard, Debatisse, Michelle, Malfoy, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC509208/
https://ncbi.nlm.nih.gov/pubmed/15269346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402979101
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