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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

Population and family-based genetic studies typically result in the identification of genetic variants that are statistically associated with a clinical disease or phenotype. For many diseases and traits, most variants are non-coding, and are thus likely to act by impacting subtle, comparatively har...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: Miller, Daniel E., Patel, Zubin H., Lu, Xiaoming, Lynch, Arthur T., Weirauch, Matthew T., Kottyan, Leah C.
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5091922/
https://ncbi.nlm.nih.gov/pubmed/27585267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/54093
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