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The ion channel of F-ATP synthase is the target of toxic organotin compounds

ATP is the universal energy currency of living cells, and the majority of it is synthesized by the F(1)F(0) ATP synthase. Inhibitors of this enzyme are therefore potentially detrimental for all life forms. Tributyltin chloride (TBT-Cl) inhibits ATP hydrolysis by the Na(+)-translocating ATP synthase...

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Autores principales: von Ballmoos, Christoph, Brunner, Josef, Dimroth, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC509188/
https://ncbi.nlm.nih.gov/pubmed/15277681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402869101
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