Targeting HMGA2 in Retinoblastoma Cells in vitro Using the Aptamer Strategy

High-mobility group A2 (HMGA2) protein regulates retinoblastoma (RB) cancer cell proliferation. Here, a stable phosphorothioate-modified HMGA2 aptamer was used to block HMGA2 protein function in RB cells. HMGA2-aptamer internalisation in RB cells (Y79, Weri Rb1) and non-neoplastic human retinal cell...

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Detalhes bibliográficos
Publicado no:Ocul Oncol Pathol
Main Authors: Nalini, Venkatesan, Deepa, Perinkulam Ravi, Raguraman, Rajeswari, Khetan, Vikas, Reddy, Maddy Ashwin, Krishnakumar, Subramanian
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2016
Assuntos:
Basic Science Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5091129/
https://ncbi.nlm.nih.gov/pubmed/27843907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000447300
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