Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) on Pharmacokinetics and Central Nervous System Penetration of Abacavir and Zidovudine in the Mouse

Many anti-human immunodeficiency virus 1 nucleoside reverse-transcriptase inhibitors have low central nervous system (CNS) distribution due in part to active efflux transport at the blood-brain barrier. We have previously shown that zidovudine (AZT) and abacavir (ABC) are in vitro substrates for the...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Giri, Nagdeep, Shaik, Naveed, Pan, Guoyu, Terasaki, Tetsuya, Mukai, Chisato, Kitagaki, Shinji, Miyakoshi, Naoki, Elmquist, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5091086/
https://ncbi.nlm.nih.gov/pubmed/18443033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.020974
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