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Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design

In vitro assays are frequently used for the screening of substrates and inhibitors of transporter-mediated efflux. Examining directional flux across Madin-Darby canine kidney (MDCK) II cell monolayers that overexpress a transporter protein is particularly useful in identifying whether or not a candi...

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Detalhes bibliográficos
Main Authors: Giri, Nagdeep, Agarwal, Sagar, Shaik, Naveed, Pan, Guoyu, Chen, Ying, Elmquist, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680510/
https://ncbi.nlm.nih.gov/pubmed/19056916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.022046
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