Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction.

Lyso-phospholipids exert a major injurious effect on lung cell membranes during Acute Respiratory Distress Syndrome (ARDS), but the mechanisms leading to their in vivo generation are still unknown. Intratracheal administration of LPS to guinea pigs induced the secretion of type II secretory phosphol...

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Detalhes bibliográficos
Main Authors: Arbibe, L, Koumanov, K, Vial, D, Rougeot, C, Faure, G, Havet, N, Longacre, S, Vargaftig, B B, Béréziat, G, Voelker, D R, Wolf, C, Touqui, L
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC509098/
https://ncbi.nlm.nih.gov/pubmed/9739049
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