Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release

Thrombosis and its complications are the leading cause of death in patients with diabetes. Metformin, a first-line therapy for type 2 diabetes, is the only drug demonstrated to reduce cardiovascular complications in diabetic patients. However, whether metformin can effectively prevent thrombosis and...

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Published in:Sci Rep
Main Authors: Xin, Guang, Wei, Zeliang, Ji, Chengjie, Zheng, Huajie, Gu, Jun, Ma, Limei, Huang, Wenfang, Morris-Natschke, Susan L., Yeh, Jwu-Lai, Zhang, Rui, Qin, Chaoyi, Wen, Li, Xing, Zhihua, Cao, Yu, Xia, Qing, Lu, Yanrong, Li, Ke, Niu, Hai, Lee, Kuo-Hsiung, Huang, Wen
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5090250/
https://ncbi.nlm.nih.gov/pubmed/27805009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36222
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