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Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis

Identification and annotation of functional residues are fundamental questions in protein sequence analysis. Sequence and structure conservation provides valuable information to tackle these questions. It is, however, limited by the incomplete sampling of sequence space in natural evolution. Moreove...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:mBio
Prif Awduron: Du, Yushen, Wu, Nicholas C., Jiang, Lin, Zhang, Tianhao, Gong, Danyang, Shu, Sara, Wu, Ting-Ting, Sun, Ren
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5090041/
https://ncbi.nlm.nih.gov/pubmed/27803181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01801-16
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