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Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis

Identification and annotation of functional residues are fundamental questions in protein sequence analysis. Sequence and structure conservation provides valuable information to tackle these questions. It is, however, limited by the incomplete sampling of sequence space in natural evolution. Moreove...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Du, Yushen, Wu, Nicholas C., Jiang, Lin, Zhang, Tianhao, Gong, Danyang, Shu, Sara, Wu, Ting-Ting, Sun, Ren
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5090041/
https://ncbi.nlm.nih.gov/pubmed/27803181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01801-16
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