Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality

Viruses often encode proteins with multiple functions due to their compact genomes. Existing approaches to identify functional residues largely rely on sequence conservation analysis. Inferring functional residues from sequence conservation can produce false positives, in which the conserved residue...

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Detaylı Bibliyografya
Yayımlandı:PLoS Genet
Asıl Yazarlar: Wu, Nicholas C., Olson, C. Anders, Du, Yushen, Le, Shuai, Tran, Kevin, Remenyi, Roland, Gong, Danyang, Al-Mawsawi, Laith Q., Qi, Hangfei, Wu, Ting-Ting, Sun, Ren
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489113/
https://ncbi.nlm.nih.gov/pubmed/26132554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005310
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