Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality

Viruses often encode proteins with multiple functions due to their compact genomes. Existing approaches to identify functional residues largely rely on sequence conservation analysis. Inferring functional residues from sequence conservation can produce false positives, in which the conserved residue...

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Dades bibliogràfiques
Publicat a:PLoS Genet
Autors principals: Wu, Nicholas C., Olson, C. Anders, Du, Yushen, Le, Shuai, Tran, Kevin, Remenyi, Roland, Gong, Danyang, Al-Mawsawi, Laith Q., Qi, Hangfei, Wu, Ting-Ting, Sun, Ren
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489113/
https://ncbi.nlm.nih.gov/pubmed/26132554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005310
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