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GENERATING LATE-ONSET HUMAN iPSC-BASED DISEASE MODELS BY INDUCING NEURONAL AGE-RELATED PHENOTYPES THROUGH TELOMERASE MANIPULATION
Modeling late onset disorders such as Parkinson’s disease (PD) using iPSC technology remains a challenge as current differentiation protocols yield cells with the properties of fetal-stage cells. Here we tested whether it is possible to accelerate aging in vitro to trigger late onset disease phenoty...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5089807/ https://ncbi.nlm.nih.gov/pubmed/27760320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.062 |
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