Human iPSC-based Modeling of Late-Onset Disease via Progerin-induced Aging

Reprogramming somatic cells to induced pluripotent stem cells (iPSCs), resets their identity back to an embryonic age, and thus presents a significant hurdle for modeling late-onset disorders. In this study, we describe a strategy for inducing aging-related features in human iPSC-derived lineages an...

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Detalhes bibliográficos
Main Authors: Miller, Justine D., Ganat, Yosif M., Kishinevsky, Sarah, Bowman, Robert L., Liu, Becky, Tu, Edmund Y., Mandal, Pankaj, Vera, Elsa, Shim, Jae-won, Kriks, Sonja, Taldone, Tony, Fusaki, Noemi, Tomishima, Mark J., Krainc, Dimitri, Milner, Teresa A., Rossi, Derrick J., Studer, Lorenz
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153390/
https://ncbi.nlm.nih.gov/pubmed/24315443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.11.006
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