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Simvastatin inhibits neural cell apoptosis and promotes locomotor recovery via activation of Wnt/β‐catenin signaling pathway after spinal cord injury

Statins exhibit neuroprotective effects after spinal cord injury (SCI). However, the molecular mechanism underlying these effects remains unknown. This study demonstrates that the hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin (Simv) exhibits neuroprotective effects on neuronal apo...

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Dades bibliogràfiques
Publicat a:J Neurochem
Autors principals: Gao, Kai, Shen, Zhaoliang, Yuan, Yajiang, Han, Donghe, Song, Changwei, Guo, Yue, Mei, Xifan
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089634/
https://ncbi.nlm.nih.gov/pubmed/26443048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13382
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