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Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens

PURPOSE: Many proteins in the lens undergo extensive posttranslational modifications (PTMs) with age, leading to alterations in their function. The extent to which lens gap junction proteins, Cx46 and Cx50, accumulate PTMs with aging is not known. In this study, we identified truncations in Cx46 and...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Slavi, Nefeli, Wang, Zhen, Harvey, Lucas, Schey, Kevin L., Srinivas, Miduturu
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089213/
https://ncbi.nlm.nih.gov/pubmed/27787559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-19698
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