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Connexin 46 (Cx46) Gap Junctions Provide a Pathway for the Delivery of Glutathione to the Lens Nucleus

Maintenance of adequate levels of glutathione (GSH) in the lens nucleus is critical for protection of lens proteins from the effects of oxidative stress and for lens transparency. How GSH is transported to the nucleus is unknown. We show that GSH diffuses to the nucleus from the outer cortex, where...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Slavi, Nefeli, Rubinos, Clio, Li, Leping, Sellitto, Caterina, White, Thomas W., Mathias, Richard, Srinivas, Miduturu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239621/
https://ncbi.nlm.nih.gov/pubmed/25294879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597898
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