Effects of flavopiridol on critical regulation pathways of CD133(high)/CD44(high) lung cancer stem cells

BACKGROUND: Flavopiridol a semisynthetic flavone that inhibits cyclin-dependent kinases (CDKs) and has growth-inhibitory activity and induces a blockade of cell-cycle progression at G1-phase and apoptosis in numerous human tumor cell lines and is currently under investigation in phase II clinical tr...

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Vydáno v:Medicine (Baltimore)
Hlavní autoři: Bozok Cetintas, Vildan, Acikgoz, Eda, Yigitturk, Gurkan, Demir, Kenan, Oktem, Gulperi, Tezcanli Kaymaz, Burçin, Oltulu, Fatih, Aktug, Huseyin
Médium: Artigo
Jazyk:Inglês
Vydáno: Wolters Kluwer Health 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089099/
https://ncbi.nlm.nih.gov/pubmed/27787370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MD.0000000000005150
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