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Substitution of the carboxyl-terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout mice.

HDL metabolism and atherosclerosis were studied in apo E knockout (KO) mice overexpressing human apo AI, a des- (190-243)-apo AI carboxyl-terminal deletion mutant of human apo AI or an apo AI-(1-189)-apo AII-(12-77) chimera in which the carboxyl-terminal domain of apo AI was substituted with the pai...

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Autors principals: Holvoet, P, Danloy, S, Deridder, E, Lox, M, Bernar, H, Dhoest, A, Collen, D
Format: Artigo
Idioma:Inglês
Publicat: 1998
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC508896/
https://ncbi.nlm.nih.gov/pubmed/9664079
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