A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion.

Lowering of the plasma FFA level in intact fasted rats by infusion of nicotinic acid (NA) caused essentially complete ablation of insulin secretion (IS) in response to a subsequent intravenous bolus of arginine, leucine, or glibenclamide (as previously found using glucose as the beta-cell stimulus)....

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Bibliographic Details
Main Authors: Dobbins, R L, Chester, M W, Stevenson, B E, Daniels, M B, Stein, D T, McGarry, J D
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC508826/
https://ncbi.nlm.nih.gov/pubmed/9616208
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