QR Code

The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.

We investigated the effect of the acute promyelocytic leukemia (APL) specific PML/RARalpha fusion protein on the sensitivity to TNF-alpha-mediated apoptosis. The U937 leukemia cell line was transduced with PML/RARalpha cDNA. PML/RARalpha expression caused a markedly reduced sensitivity to TNF-alpha,...

Full description

Saved in:
Published in:J Clin Invest
Main Authors: Testa, U, Grignani, F, Samoggia, P, Zanetti, C, Riccioni, R, Lo Coco, F, Diverio, D, Felli, N, Passerini, C G, Grell, M, Pelicci, P G, Peschle, C
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508816/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9593784/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1332
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items