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The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.

We investigated the effect of the acute promyelocytic leukemia (APL) specific PML/RARalpha fusion protein on the sensitivity to TNF-alpha-mediated apoptosis. The U937 leukemia cell line was transduced with PML/RARalpha cDNA. PML/RARalpha expression caused a markedly reduced sensitivity to TNF-alpha,...

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Udgivet i:J Clin Invest
Principais autores: Testa, U, Grignani, F, Samoggia, P, Zanetti, C, Riccioni, R, Lo Coco, F, Diverio, D, Felli, N, Passerini, C G, Grell, M, Pelicci, P G, Peschle, C
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508816/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9593784/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1332
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