Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase.

Inotropic and chronotropic responses to catecholamines in young adult transgenic mice overexpressing myocardial Gsalpha are enhanced. One might predict that over the life of the animal, this chronically enhanced beta-adrenergic receptor stimulation would result in homologous catecholamine desensitiz...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Vatner, D E, Asai, K, Iwase, M, Ishikawa, Y, Wagner, T E, Shannon, R P, Homcy, C J, Vatner, S F
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508778/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9576756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1530
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