Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase.

Inotropic and chronotropic responses to catecholamines in young adult transgenic mice overexpressing myocardial Gsalpha are enhanced. One might predict that over the life of the animal, this chronically enhanced beta-adrenergic receptor stimulation would result in homologous catecholamine desensitiz...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Vatner, D E, Asai, K, Iwase, M, Ishikawa, Y, Wagner, T E, Shannon, R P, Homcy, C J, Vatner, S F
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1998
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508778/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9576756/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1530
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