Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase.

Inotropic and chronotropic responses to catecholamines in young adult transgenic mice overexpressing myocardial Gsalpha are enhanced. One might predict that over the life of the animal, this chronically enhanced beta-adrenergic receptor stimulation would result in homologous catecholamine desensitiz...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Vatner, D E, Asai, K, Iwase, M, Ishikawa, Y, Wagner, T E, Shannon, R P, Homcy, C J, Vatner, S F
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1998
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508778/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9576756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1530
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