Blockade of CC chemokine receptor 5 (CCR5)-tropic human immunodeficiency virus-1 replication in human lymphoid tissue by CC chemokines.

The CC chemokines MIP-1alpha, MIP-1beta, and RANTES suppress replication of certain HIV-1 strains in cultured PBMC and T cell lines by blocking interaction of gp120 with CC chemokine receptor 5 (CCR5). However, the same chemokines can enhance HIV-1 replication in cultured macrophages. The net effect...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Margolis, L B, Glushakova, S, Grivel, J C, Murphy, P M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508773/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9576751/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI2015
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