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Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probed by High Resolution Field Cycling (31)P NMR Relaxometry
Guanosine-5′-monophosphate reductase (GMPR) catalyzes the reduction of GMP to IMP and ammonia with concomitant oxidation of NADPH. Here we investigated the structure and dynamics of enzyme-bound substrates and cofactors by measuring (31)P relaxation rates over a large magnetic field range using high...
Gorde:
| Argitaratua izan da: | J Biol Chem |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Biochemistry and Molecular Biology
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5087720/ https://ncbi.nlm.nih.gov/pubmed/27613871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.739516 |
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