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Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C
The spindle assembly checkpoint (SAC) inhibits the anaphase-promoting complex/cyclosome (APC/C) in response to unattached kinetochores by generating a diffusible inhibitor termed the mitotic checkpoint complex (MCC). At metaphase, rapid activation of the APC/C requires removal of the MCC, a process...
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| 發表在: | Biol Open |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Company of Biologists Ltd
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5087681/ https://ncbi.nlm.nih.gov/pubmed/27591192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.020842 |
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