Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.

An arginine to glutamine missense mutation at position 403 of the beta-cardiac myosin heavy chain causes familial hypertrophic cardiomyopathy. Here we study mice which have this same missense mutation (alphaMHC403/+) using an isolated, isovolumic heart preparation where cardiac performance is measur...

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Publié dans:	J Clin Invest
Auteurs principaux:	Spindler, M, Saupe, K W, Christe, M E, Sweeney, H L, Seidman, C E, Seidman, J G, Ingwall, J S
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1998
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508760/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9541509/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1940
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