Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis

The inflammasome adaptor protein, ASC, contributes to both innate immune responses and inflammatory diseases via self-oligomerization, which leads to the activation of the protease, caspase-1. Here, we report that the cytosolic tyrosine kinases, FAK and Pyk2, are differentially involved in NLRP3 and...

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Udgivet i:Sci Rep
Main Authors: Chung, I-Che, OuYang, Chun-Nan, Yuan, Sheng-Ning, Li, Hsin-Pai, Chen, Jeng-Ting, Shieh, Hui-Ru, Chen, Yu-Jen, Ojcius, David M., Chu, Ching-Liang, Yu, Jau-Song, Chang, Yu-Sun, Chen, Lih-Chyang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087076/
https://ncbi.nlm.nih.gov/pubmed/27796369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36214
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