Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity

Melanocortin-4 receptor (Mc4r)–expressing neurons in the autonomic nervous system, particularly in the paraventricular nucleus of the hypothalamus (PVH), play an essential role in blood pressure (BP) control. Mc4r-deficient (Mc4rKO) mice are severely obese but lack obesity-related hypertension; they...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Samuelsson, Anne-Maj S., Mullier, Amandine, Maicas, Nuria, Oosterhuis, Nynke R., Eun Bae, Sung, Novoselova, Tatiana V., Chan, Li F., Pombo, Joaquim M., Taylor, Paul D., Joles, Jaap A., Coen, Clive W., Balthasar, Nina, Poston, Lucilla
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087049/
https://ncbi.nlm.nih.gov/pubmed/27791019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607464113
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