Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity

Melanocortin-4 receptor (Mc4r)–expressing neurons in the autonomic nervous system, particularly in the paraventricular nucleus of the hypothalamus (PVH), play an essential role in blood pressure (BP) control. Mc4r-deficient (Mc4rKO) mice are severely obese but lack obesity-related hypertension; they...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Samuelsson, Anne-Maj S., Mullier, Amandine, Maicas, Nuria, Oosterhuis, Nynke R., Eun Bae, Sung, Novoselova, Tatiana V., Chan, Li F., Pombo, Joaquim M., Taylor, Paul D., Joles, Jaap A., Coen, Clive W., Balthasar, Nina, Poston, Lucilla
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087049/
https://ncbi.nlm.nih.gov/pubmed/27791019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607464113
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