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Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration

Despite the recognized role of tumor necrosis factor (TNF) in inflammation and neuronal degeneration, anti-TNF therapeutics failed to treat neurodegenerative diseases. Animal disease models had revealed the antithetic effects of the two TNF receptors (TNFR) in the central nervous system, whereby TNF...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Dong, Yun, Fischer, Roman, Naudé, Petrus J. W., Maier, Olaf, Nyakas, Csaba, Duffey, Maëlle, Van der Zee, Eddy A., Dekens, Doortje, Douwenga, Wanda, Herrmann, Andreas, Guenzi, Eric, Kontermann, Roland E., Pfizenmaier, Klaus, Eisel, Ulrich L. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087045/
https://ncbi.nlm.nih.gov/pubmed/27791020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605195113
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