Enhanced expression of p53 and apoptosis induced by blockade of the vacuolar proton ATPase in cardiomyocytes.

Activation of the vacuolar proton ATPase (VPATPase) has been implicated in the prevention of apoptosis in neutrophils and adult cardiac myocytes. To determine the role of the VPATPase in apoptosis of cardiac myocytes, we used a potent and specific inhibitor of the VPATPase, bafilomycin A1. Bafilomyc...

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Autors principals: Long, X, Crow, M T, Sollott, S J, O'Neill, L, Menees, D S, de Lourdes Hipolito, M, Boluyt, M O, Asai, T, Lakatta, E G
Format: Artigo
Idioma:Inglês
Publicat: 1998
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC508701/
https://ncbi.nlm.nih.gov/pubmed/9502788
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