Enhanced expression of p53 and apoptosis induced by blockade of the vacuolar proton ATPase in cardiomyocytes.

Activation of the vacuolar proton ATPase (VPATPase) has been implicated in the prevention of apoptosis in neutrophils and adult cardiac myocytes. To determine the role of the VPATPase in apoptosis of cardiac myocytes, we used a potent and specific inhibitor of the VPATPase, bafilomycin A1. Bafilomyc...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Long, X, Crow, M T, Sollott, S J, O'Neill, L, Menees, D S, de Lourdes Hipolito, M, Boluyt, M O, Asai, T, Lakatta, E G
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508701/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9502788/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI345
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