Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.

The antitumor effect and mechanisms activated by murine IL-12 and IL-18, cytokines that induce IFN-gamma production, were studied using engineered SCK murine mammary carcinoma cells. In syngeneic A/J mice, SCK cells expressing mIL-12 or mIL-18 were less tumorigenic and formed tumors more slowly than...

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Autores principales: Coughlin, C M, Salhany, K E, Wysocka, M, Aruga, E, Kurzawa, H, Chang, A E, Hunter, C A, Fox, J C, Trinchieri, G, Lee, W M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1998
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC508700/
https://ncbi.nlm.nih.gov/pubmed/9502787
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