Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms

Epigenetic memory, in particular DNA methylation, is established during development in differentiating cells and must be erased to create naïve (induced) pluripotent stem cells. The ten-eleven translocation (TET) enzymes can catalyze the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Hore, Timothy Alexander, von Meyenn, Ferdinand, Ravichandran, Mirunalini, Bachman, Martin, Ficz, Gabriella, Oxley, David, Santos, Fátima, Balasubramanian, Shankar, Jurkowski, Tomasz P., Reik, Wolf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2016
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086989/
https://ncbi.nlm.nih.gov/pubmed/27729528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608679113
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