Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms

Epigenetic memory, in particular DNA methylation, is established during development in differentiating cells and must be erased to create naïve (induced) pluripotent stem cells. The ten-eleven translocation (TET) enzymes can catalyze the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Hore, Timothy Alexander, von Meyenn, Ferdinand, Ravichandran, Mirunalini, Bachman, Martin, Ficz, Gabriella, Oxley, David, Santos, Fátima, Balasubramanian, Shankar, Jurkowski, Tomasz P., Reik, Wolf
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086989/
https://ncbi.nlm.nih.gov/pubmed/27729528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608679113
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