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Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms

Epigenetic memory, in particular DNA methylation, is established during development in differentiating cells and must be erased to create naïve (induced) pluripotent stem cells. The ten-eleven translocation (TET) enzymes can catalyze the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Hore, Timothy Alexander, von Meyenn, Ferdinand, Ravichandran, Mirunalini, Bachman, Martin, Ficz, Gabriella, Oxley, David, Santos, Fátima, Balasubramanian, Shankar, Jurkowski, Tomasz P., Reik, Wolf
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086989/
https://ncbi.nlm.nih.gov/pubmed/27729528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608679113
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