Notch3 drives development and progression of cholangiocarcinoma

The prognosis of cholangiocarcinoma (CC) is dismal. Notch has been identified as a potential driver; forced exogenous overexpression of Notch1 in hepatocytes results in the formation of biliary tumors. In human disease, however, it is unknown which components of the endogenously signaling pathway ar...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Guest, Rachel V., Boulter, Luke, Dwyer, Benjamin J., Kendall, Timothy J., Man, Tak-Yung, Minnis-Lyons, Sarah E., Lu, Wei-Yu, Robson, Andrew J., Gonzalez, Sofia Ferreira, Raven, Alexander, Wojtacha, Davina, Morton, Jennifer P., Komuta, Mina, Roskams, Tania, Wigmore, Stephen J., Sansom, Owen J., Forbes, Stuart J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086988/
https://ncbi.nlm.nih.gov/pubmed/27791012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600067113
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