Notch3 drives development and progression of cholangiocarcinoma

The prognosis of cholangiocarcinoma (CC) is dismal. Notch has been identified as a potential driver; forced exogenous overexpression of Notch1 in hepatocytes results in the formation of biliary tumors. In human disease, however, it is unknown which components of the endogenously signaling pathway ar...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Guest, Rachel V., Boulter, Luke, Dwyer, Benjamin J., Kendall, Timothy J., Man, Tak-Yung, Minnis-Lyons, Sarah E., Lu, Wei-Yu, Robson, Andrew J., Gonzalez, Sofia Ferreira, Raven, Alexander, Wojtacha, Davina, Morton, Jennifer P., Komuta, Mina, Roskams, Tania, Wigmore, Stephen J., Sansom, Owen J., Forbes, Stuart J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2016
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086988/
https://ncbi.nlm.nih.gov/pubmed/27791012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600067113
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