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Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module

The SAGA complex contains two enzymatic modules, which house histone acetyltransferase (HAT) and deubiquitinase (DUB) activities. USP22 is the catalytic subunit of the DUB module, but two adaptor proteins, ATXN7L3 and ENY2, are necessary for DUB activity toward histone H2Bub1 and other substrates. A...

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Détails bibliographiques
Publié dans:Mol Cell Biol
Auteurs principaux: Li, Wenqian, Atanassov, Boyko S., Lan, Xianjiang, Mohan, Ryan D., Swanson, Selene K., Farria, Aimee T., Florens, Laurence, Washburn, Michael P., Workman, Jerry L., Dent, Sharon Y. R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086525/
https://ncbi.nlm.nih.gov/pubmed/27601583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00193-16
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