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Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module

The SAGA complex contains two enzymatic modules, which house histone acetyltransferase (HAT) and deubiquitinase (DUB) activities. USP22 is the catalytic subunit of the DUB module, but two adaptor proteins, ATXN7L3 and ENY2, are necessary for DUB activity toward histone H2Bub1 and other substrates. A...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Main Authors: Li, Wenqian, Atanassov, Boyko S., Lan, Xianjiang, Mohan, Ryan D., Swanson, Selene K., Farria, Aimee T., Florens, Laurence, Washburn, Michael P., Workman, Jerry L., Dent, Sharon Y. R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086525/
https://ncbi.nlm.nih.gov/pubmed/27601583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00193-16
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