Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function

Loss of von Hippel Lindau (VHL) protein function is a key driver of VHL diseases, including sporadic and inherited clear cell renal cell carcinoma. Modulation of the proteostasis of VHL, especially missense point-mutated VHL, is a promising approach to augmenting VHL levels and function. VHL proteos...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: German, Peter, Bai, Shanshan, Liu, Xian-De, Sun, Mianen, Zhou, Lijun, Kalra, Sarathi, Zhang, Xuesong, Minelli, Rosalba, Scott, Kenneth L., Mills, Gordon B., Jonasch, Eric, Ding, Zhiyong
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086402/
https://ncbi.nlm.nih.gov/pubmed/26973240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.40
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