Agents that Stabilize Mutated von Hippel Lindau Protein Result in Differential Post-Translational Modification and Subcellular Localization: Results of a High Throughput Screen to Identify Compounds that Modulate VHL Proteostasis

BACKGROUND: von Hippel Lindau (VHL) disease is an autosomal dominant inherited disorder that results in multiple organ systems being affected. Treatment is mainly surgical, however, effective systemic therapies are needed. We developed and tested a cell-based screening tool to identify compounds tha...

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Detalhes bibliográficos
Main Authors: Ding, Zhiyong, German, Peter, Bai, Shanshan, Feng, Zhehui, Gao, Meng, Si, Wendy, Sobieski, Mary M., Stephan, Clifford C., Mills, Gordon B., Jonasch, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895461/
https://ncbi.nlm.nih.gov/pubmed/22357874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057112436557
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