Genetic and Pharmacological Strategies to Refunctionalize the von Hippel Lindau R167Q Mutant Protein

Aberrant von Hippel Lindau (VHL) protein function is the underlying driver of VHL-related diseases, including both sporadic and inherited clear cell renal cell carcinoma (ccRCC). About one third of VHL mutations are missense point mutations, with R167Q being the most common VHL point mutation in her...

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Detalhes bibliográficos
Main Authors: Ding, Zhiyong, German, Peter, Bai, Shanshan, Reddy, A. Srinivas, Liu, Xian-De, Sun, Mianen, Zhou, Lijun, Chen, Xiaohua, Zhao, Xiaobei, Wu, Chengbiao, Zhang, Shuxing, Mills, Gordon B., Jonasch, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047720/
https://ncbi.nlm.nih.gov/pubmed/24755468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3213
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