Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Recapitulate the Predilection of Breast Cancer Patients to Doxorubicin–Induced Cardiotoxicity

Doxorubicin (Adriamycin) is an anthracycline chemotherapy agent effective in treating a wide range of malignancies with a well–established dose–response cardiotoxic side effect that can lead to heart failure. At present, it is not possible to predict which patients will be affected by doxorubicin-in...

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Publicado en:Nat Med
Main Authors: Burridge, Paul W., Li, Yong Fuga, Matsa, Elena, Wu, Haodi, Ong, Sang–Ging, Sharma, Arun, Holmström, Alexandra, Chang, Alex C., Coronado, Michael J., Ebert, Antje D., Knowles, Joshua W., Telli, Melinda L., Witteles, Ronald M., Blau, Helen M., Bernstein, Daniel, Altman, Russ B., Wu, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086256/
https://ncbi.nlm.nih.gov/pubmed/27089514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4087
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