Expression of CD4 in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex.

We have generated a transgenic mouse line in which a CD4 transgene is expressed on a significant fraction of the mature CD8+ lymphocytes but is not expressed in the thymus. This provides an opportunity to examine the functional consequences of CD4 expression in a population of class I-selected CD8+...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Robey, E, Ramsdell, F, Elliott, J, Raulet, D, Kioussis, D, Axel, R, Fowlkes, B J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50861/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1824875/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.2.608
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