Inducing G2/M Cell Cycle Arrest and Apoptosis through Generation Reactive Oxygen Species (ROS)-Mediated Mitochondria Pathway in HT-29 Cells by Dentatin (DEN) and Dentatin Incorporated in Hydroxypropyl-β-Cyclodextrin (DEN-HPβCD)

Dentatin (DEN), purified from the roots of Clausena excavata Burm f., has poor aqueous solubility that reduces its therapeutic application. The aim of this study was to assess the effects of DEN-HPβCD (hydroxypropyl-β-cyclodextrin) complex as an anticancer agent in HT29 cancer cell line and compare...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Ashwaq, Al-Abboodi Shakir, Al-Qubaisi, Mothanna Sadiq, Rasedee, Abdullah, Abdul, Ahmad Bustamam, Taufiq-Yap, Yun Hin, Yeap, Swee Keong
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085686/
https://ncbi.nlm.nih.gov/pubmed/27763535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17101653
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